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KMID : 0603520000050010007
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 1 p.7 ~ p.14
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Effect of Korea Red Ginseng-Mixed Formula on Tumor Growth and Metastasis
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Yoon Taek-Joon
Do Jae-Ho
Kim Sung-Hoon
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Abstract
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The study was performed to evaluate the anticancer effect of Korea Red Gonseng Mixed Formula (KRGF) consisting of Korean Red Ginseng, Ganoderma, Cinnamomi Cortex, Glycyrrhizae Radix, Laminaria, Oldenlandiae diffusae Herba, Houttuyniae Herba and Agrimoniae Herba as compared with positive control, Korea red Ginseng (KRG). IC50s of cytotoxicity of KRGF and KRG against tumor cells such as A549, B16-BL6, SK-OV and SK-MEL. were over 1 ㎎/㎖. T/C% of KRG and KRGF in S-180 bearing mice were 106.3% and 134.4% respectively. KRG and KRGF showed the proliferation of spleen cells up to 141% and 264% respectively by 3[H]-thymidine uptake assay. KRGF increased CD3+, CD4+ and CD8+ cells in a dose dependent manner more than KRG, suggesting its close relation with cellular immunology. KRGF inhibited the adhesion of A549 to matrigel up to 82% at a concentration of 1 mg/ml. KRG and KRGF disrupted chicken chorioallantoic membrane (CAM) up to 20% and 80%, repectively at 15 ㎍/㎖. KRGF also extered 27% inhibition of the control in lung matastasis with B16BL6 while KRG didn´t. These results suggest KRGF has the stronger antitumor and antimetastatic effects than KRG.
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KEYWORD
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Korean Red Ginseng, KRGF, Cytotoxicity, FACS, Tumor growth@Metastasis
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